Abstract
Contemporary medicinal chemistry faces diverse challenges from several directions, including the need for both potency and specificity of any therapeutic agent. Therefore, in the present perspective, the triazolothiadiazoles and triazolothiadiazines with broad spectrum biological profile have matured into indispensable heterocyclic scaffolds. This review article is an effort to summarize medicinal chemistry investigations over the last decade, in search for new N-bridged heterocycles which can be a rich source of promising biological activities.
Copyright © 2013 Elsevier Masson SAS. All rights reserved.
MeSH terms
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Anti-Infective Agents / chemical synthesis
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology
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Anti-Inflammatory Agents / chemical synthesis
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Chemistry, Pharmaceutical / methods*
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Chemistry, Pharmaceutical / trends
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Humans
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Models, Chemical
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Molecular Structure
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Thiadiazines / chemical synthesis*
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Thiadiazines / chemistry
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Thiadiazines / pharmacology
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Thiadiazoles / chemical synthesis*
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Thiadiazoles / chemistry
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Thiadiazoles / pharmacology
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Triazoles / chemistry*
Substances
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Anti-Infective Agents
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Anti-Inflammatory Agents
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Antineoplastic Agents
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Thiadiazines
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Thiadiazoles
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Triazoles